#Blue cross focalpoint drivers

Overactivity of the mammalian (or mechanistic) target of rapamycin complex 1 (mTORC1) is central to many of these processes 3, and dampening mTORC1 activity by its allosteric inhibitor rapamycin is one of the most effective interventions to prolong life 4. Each biological process fulfils three hallmark criteria: (1) it occurs during normal aging, (2) intensifying the process accelerates aging, and (3) dampening the process delays aging. Recently, nine processes involved in aging were proposed 2, namely cellular senescence, stem cell exhaustion, genomic instability, telomere attrition, loss of proteostasis, deregulation of nutrient sensing, epigenetic alterations, mitochondrial dysfunction, and altered intracellular communication. Sarcopenia constrains physical activity, degrades the quality of life, and is a major burden on society 1. Rapid advances in treating life-threatening, age-related diseases, such as cancer and cardiovascular disease, have extended human lifespan in many countries, but exposed other age-related diseases, including sarcopenia, the age-related loss of muscle mass and strength.

#Blue cross focalpoint drivers

We uncover inter-muscle divergence in the primary drivers of sarcopenia and identify the neuromuscular junction as a focal point of mTORC1-driven muscle aging.

Through integration of comprehensive physiological and extensive gene expression profiling in young and old mice, and following genetic activation or pharmacological inhibition of mTORC1, we establish the phenotypically-backed, mTORC1-focused, multi-muscle gene expression atlas, SarcoAtlas (), as a user-friendly gene discovery tool. We demonstrate that chronic mTORC1 inhibition with rapamycin is overwhelmingly, but not entirely, positive for aging mouse skeletal muscle, while genetic, muscle fiber-specific activation of mTORC1 is sufficient to induce molecular signatures of sarcopenia. Here, we address the question of whether mTORC1 activation or suppression is beneficial for skeletal muscle aging.

mTORC1 promotes skeletal muscle hypertrophy, but also drives organismal aging. Nanette Mickiewicz, president of the sole Santa Cruz County Dignity Health facility, said Tuesday that the hospital team communicated regularly with patients and community members who were concerned about their health care coverage during the negotiation process.With human median lifespan extending into the 80s in many developed countries, the societal burden of age-related muscle loss (sarcopenia) is increasing. “We are pleased to partner with Anthem in their expanded portfolio of networks and products as it will give our Sutter patients stability and access to our integrated network for years to come,” Sutter Health Chief Public Affairs Officer Grace Davis said at the time.ĭr. This includes Sutter Health patients, who may have switched over when Sutter Health announced their successful negotiations with Anthem in July. This agreement ensures we can continue to provide value-driven care for Anthem members.”Īll care provided at Dignity Health since July 15 will be covered by the contract patients who made arrangements to seek their care through other providers have the option to return. “From the beginning, our goal in working with Anthem has always been about ensuring we can continue to meet the needs of our patients today and in the future. “We deeply appreciate the patience of our patients, employers, and physicians as we have worked through this process,” Quinn wrote on behalf of the system. “We value our relationships with providers, which are important to creating choices for our consumers and fulfilling our mission of improving lives and communities.”ĭignity Health described the contract procurement as a win for “patients who deserve access to local high-quality care.” “It was necessary for us to stand firm as part of our efforts to help slow the sharp rise in health care costs,” Anthem Regional Vice President John Pickett said at the start of the week. The new agreement, Anthem added in the statement, is retroactive to July 15. Robert Quinn estimated that negotiations had been going on in good faith since January. Previously, Dignity Health Medical Foundation’s Dr. Santa Cruz residents with Anthem who were upset with the finding that due to negotiation issues they could no longer utilize Dignity Health services can sigh a breath of relief.Īnthem leadership said in a statement that it understood that waiting for a resolution was not easy for consumers. SANTA CRUZ - Anthem Blue Cross and Dignity Health announced a new agreement late Monday that will return Dignity providers to Anthem health plans through April 2025.